Horseshoe Crab Hemocyte-derived Antimicrobial Polypeptides, Tachystatins, with Sequence Similarity to Spider Neurotoxins
نویسندگان
چکیده
منابع مشابه
Interaction between tachyplesin I, an antimicrobial peptide derived from horseshoe crab, and lipopolysaccharide.
Lipopolysaccharide (LPS) is a major constituent of the outer membrane of Gram-negative bacteria and is the very first site of interactions with antimicrobial peptides (AMPs). In order to gain better insight into the interaction between LPS and AMPs, we determined the structure of tachyplesin I (TP I), an antimicrobial peptide derived from horseshoe crab, in its bound state with LPS and proposed...
متن کاملProtecting Horseshoe Crab Habitat
Each spring adult horseshoe crabs migrate from deep bay waters and the Atlantic continental shelf to intertidal sandy beaches to spawn. Horseshoe crabs are an important food source for migrating shorebirds that feed on the eggs, for migrating fish that feed on the eggs and larvae and for Atlantic loggerhead turtles that feed on horseshoe crabs while using the Chesapeake Bay as a summer nursery ...
متن کاملComparison of Antimicrobial Properties and Toxicity of Natural S3 Peptide with Horseshoe Crab Amoebocyte Origin and its Mutants
Introduction: Antimicrobial peptides (AMPs) are compounds with antimicrobial properties that are studied widely due to the development of resistance of pathogenic bacteria to antibiotics. In the present study, the toxicity and antimicrobial effects of two natural monomeric peptides (S3 and S∆3) were compared with S3-S∆3 hybrids and S3 tetramers. Material & Methods: Protein hybrids (S∆3S3-2mer-G...
متن کاملFunctional conversion of hemocyanin to phenoloxidase by horseshoe crab antimicrobial peptides.
Arthropod hemocyanins and phenoloxidases serve different physiological functions as oxygen transporters and enzymes involved in defense reactions, respectively. However, they are equipped with a structurally similar oxygen-binding center. We have shown that the clotting enzyme of the horseshoe crab, Tachypleus tridentatus, functionally converts hemocyanin to phenoloxidase by forming a complex w...
متن کاملSpider neurotoxins and their neuronal receptors
Seven high molecular weight neurotoxins which stimulate secretion of various neurotransmitters were isolated from the venom of black widow spider Latrodectus mactans tredecimauttatus. Among them a-latrotoxin is very specific for vertebrate while latroinsectotoxins are active only for insects, a-latrocrustatoxin affects crustacean nerve endings. Latrotoxin preparation consists of 130 and 8 kD pr...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1999
ISSN: 0021-9258
DOI: 10.1074/jbc.274.37.26172